Design and Manufacture of Pharmaceutical Tablets, Reynir Eyjolfsson

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esign and Manufacture of Pharmaceutical Tablets offers real world solutions and outcomes of formulation and processing challenges of pharmaceutical tablets.  This book includes numerous practical examples related to actual formulations that have been validated and marketed and covers important data in the areas of stability, dissolution, bioavailibity and processing.  It provides important background and theoretical information on design and manufacturing and includes a full section dedicated to design experimental methodology and statistics.  In addition, this book offers a a general discussion of excipients used in proper tablet design along with practical examples related to excipients.  Drug development scientists in industry and academia, as well as students in the pharmaceutical sciences will greatly benefit from the practical knowledge and case examples provided throughout this book.

Aspectos biofarmacéuticos de la evaluación de medicamentos, Hilda Lilia Cárdenas Rodríguez, Alma Rosa Cortés Arroyo, UAM

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editorial UAM; la colección de libros de texto es el resultado de la preocupación que tiene la Universidad Autónoma Metropolitana por impulsar y fortalecer la producción de libros idóneos para el desarrollo de programas de enseñanza-aprendizaje de una educación superior acorde con las realidades de nuestro país.

Análisis químico cuantitativo, Daniel C. Harris

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.djvu:  mega[PUNTO]co[Punto]nz/#!QQ8S1DaK!XRF5Vp0Eg_D4Pu2xnYSPTIk4KLY81RZt3WV2b7olxng

Además de la actualización y revisión de todo el libro, esta nueva edición introduce un capítulo independiente (el 22) sobre Espectrometría de masas y otro nuevo, el capítulo 29, sobre garantía de calidad.

Los temas han sido introducidos e ilustrados con ejemplos concretos de interés y extraídos del mundo real.

Una sucesión de recuadros a lo largo de cada capítulo amplían y explican puntos importantes que hay en el texto.

Los ejemplos resueltos están pensados como una herramienta pedagógica importante para enseñar a resolver problemas. 

Las hojas de cálculo siguen teniendo gran importancia. En esta edición se introducen por primera vez algunas herramientas muy útiles de Microsoft Excel, como el trazado de gráficos, las funciones estadísticas, la resolución de ecuaciones

Pharmaceutical preformulation and formulation, Mark Gibson, 2nd, ingles

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Written by a panel of experts, this book covers every stage of drug development, from candidate drug selection to commercial formulation. It provides practical reference and pragmatic guide on what studies need to be undertaken, for what reasons, and at what key stages of the drug development process. Going beyond coverage of preformulation, the book discusses biopharmaceuticals, drug delivery, formulation, and process development aspects of product development. The contributing authors share their experience and expertise in significant chapters divided into three useful sections: Aiding Candidate Drug Selection, Early Drug Development, and From Product Design to Commercial Dosage Form. 

Biología Celular y molecular, 5ta, Lodish, Berk

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Ofrece una introducción a las técnicas y experimentos científicos del pasado y del presente, de descubrimientos importantes que llevaron a la formación de los conceptos clave en el campo. Presenta, además, información experimental esencial con nuevos problemas de análisis de datos y perspectivas para el futuro. En esta quinta edición, los temas han sido reescritos y reorganizados de forma lógica y didáctica en siete partes que incluyen: fundamentos químicos y moleculares, organización celular y bioquímica, genética y biología molecular, señalización celular, tránsito de membrana, citoesqueleto, ciclo celular y control de la proliferación celular.En lo que respecta al diseño, el lector encontrará inéditas figuras sintetizadoras, nueva combinación de esquemas con micrografías e ilustraciones esquemáticas más consistentes, que, junto con otras innovaciones, facilitan la comprensión de la temática abordada.

Clinical Neuroanatomy, Waxman, 25th

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formato .CHM

A streamlined, comprehensive synopsis of neuroanatomy and its functional and clinical applications

For more than seventy years, Clinical Neuroanatomy has been the best way for medical students, residents, trainees in health-related fields, and clinicians in practice to gain an understanding of neuroanatomy, its functional underpinnings, and its relationship to the clinic. Emphasizing the important concepts, facts, and structures, this full-color and engagingly written text includes clear, memorable tables and diagrams, and is state of the art in pathophysiology and diagnosis and treatment of neurological disorders.

Here's why Clinical Neuroanatomy is essential for board review or as a clinical refresher:

• More than 300 full-color illustrations 
• Clinical correlations help you interpret and remember essential neuroanatomic concepts in terms of function and clinical application 
• Numerous computed tomography (CT) and magnetic resonance images (MRIs) of the normal brain and spinal cord; functional magnetic resonance images that provide a noninvasive window on brain function; and neuroimaging studies that illustrate common pathological entities that affect the nervous system 
• Coverage of the latest advances in molecular and cellular biology in the context of neuroanatomy 
• A unique Introduction to Clinical Thinking section that puts neuroanatomy in a clinical perspective 
• Clear, easy-to-read tables that encapsulate important information 
• A complete practice exam to test your knowledge 
• Coverage of the basic structure and function of the brain, spinal cord, and peripheral nerves as well as clinical presentations of disease processes involving specific structures

Análisis químico cuantitativo, 3ra, Daniel Harris

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En formato Djvu

Tratado de fisiología médica, Guyton, 11va

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Nueva edición del best seller en fisiología, y el libro más valorado por los estudiantes de Medicina a la hora de afrontar la asignatura de la Fisiología, uno de los pilares fundamentales en el que se sustentará toda su posterior formación clínica. La clave del éxito de la obra en su 12a. ed. reside en la gran capacidad que el Dr. Guyton tenía de simplificar al máximo los conceptos, concibiendo capítulos muy cortos, fáciles de leer, magníficamente ilustrados y con el grado de detalle justo. A su muerte, el Dr. Hall, quien ahora dirige en solitario la edición, toma el testigo dejado por el Dr. Guyton y mantiene al pie de la letra la filosofía de la obra y su estrucutra, que la convierte en un libro único en su género. 

Esta nueva edición presenta todos los capítulos revisados, aunque las principales novedades se encuentran en los siguientes apartados: Actualización de toda la información referente a biología molecular, Actualización y revisión de la parte de neurofisiología ( se incluye un nuevo colaborador), Actualización de la información del sistema cardiovascular y Actualización de la información del sistema gastrointestinal. Por otro lado, el Dr. Hall, al iniciar la nueva edición, consideró necesaria la revisión de todas las imágenes de la obra, ya que había algunas que no eran lo suficientemente claras y explicativas. Así, se ha incorporado la figura del ilustrador Michael Schenk, quien tiene una amplia experiencia en la ilustración de libros de texto médicos. 

Otra importante característica a destacar es que a lo largo de los diferentes capítulos hay una clara jerarquización de contenidos. Así, puede distinguirse, gracias a un tamaño de letra distinta, la información fisiológica fundamental, el need to know y el material adicional, nice to know que se presenta en un tamaño de letra inferior. Dicho material adicional, se encuentra a su vez clasificado en varías categorías. 1) información anatómica, química, necesaria para la comprensión del proceso fisiológico, 2) información fisiológica de especial relevancia para determinados campos de la medicina clínica y 3) mecanismos fisiológicos en concreto que son abordados con una gran profundidad. 

La obra cuenta con el recurso Student Consult que cuenta con los siguientes recursos: todo el texto en inglés, banco de imágenes, preguntas de autoevaluación, animaciones y títulos relacionados.

Mecanismos de reacción en química orgánica, problemas selectos y soluciones, Groutas

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El objetivo de este libro consiste en utilizar los mecanismos de las reacciones orgánicas, como un medio para facilitar el domino y entendimiento de los principios de la Química Organica. 
Esto se logra a través de una selección apropiada y haciendo uso de un gran numero de problemas seleccionados de la literatura química. Cada pregunta pretende ilustrar uno o más de los principios fundamentales de los mecanismos de reacción en química orgánica.

The chemistry of heterocycles, structures, reactions, synthesis and applications, Wiley, 2nd

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Handbook of heterocyclic chemistry, Katritzky, Pozharskii, 2nd, ingles

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Heterocyclic compounds play a vital role in the metabolism of living cells. Their practical applications range from extensive clinical use to fields as diverse as agriculture, photography, biocide formulation and polymer science. 

Written by leading scholars and industry experts, the Handbook of Heterocyclic Chemistry is thoroughly updated with over 50% new content. It has been rewritten with a new expanded author team, who have carefully distilled essential information on the reactivity, structure and synthesis of heterocycles from the 2008 major reference work Comprehensive Heterocyclic Chemistry III. To bring the work up to date the author team have also added new synthetic examples and structures, key applications and new references from 2008-2010. 

Contains more than 1500 clearly drawn structures and reactions. The highly systematic coverage given to the subject makes this one of the most authoritative single-volume accounts of modern heterocyclic chemistry available and should be useful reference for those teaching a heterocyclic course.

Name reactions in heterocyclic chemistry, Wiley, Jie Jack Li, ingles

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Covers important name reactions relevant to heterocyclic chemistry 

The field of heterocyclic chemistry has long presented a special challenge for chemists. Because of the enormous amount and variety of information, it is often a difficult topic to cover for undergraduate and graduate chemistry students, even in simplified form. Yet the chemistry of heterocyclic compounds and methods for their synthesis form the bedrock of modern medicinal chemical and pharmaceutical research. Thus there is a great need for high quality, up-to-date, and authoritative books on heterocyclic synthesis helpful to both the professional research chemist as well as the advanced student. 

Name Reactions in Heterocyclic Chemistry provides a one-stop repository for this important field of organic chemistry. The primary topics include three- and four-membered heterocycles, five-membered heterocycles including indoles, furans, thiophenes, and oxazoles, six-membered heterocycles including quinolines, isoquinolines, and pyrimidines, and other heterocycles.

Classics in total synthesis, Nicolaou, Sorensen, ingles

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This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists.

To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information.

Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins.

Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.

Heterocyclic chemistry, Sainsbury, ingles

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This book deals with the fundamental chemistry of fully saturated and unsaturated 4-, 5- and 6-membered heterocycles. The principal focus is those compounds containing a single nitrogen, oxygen or sulfur atom and by restricting discussion to these, a balanced treatment is possible. The book introduces a selection of important heterocyclic compounds and the vital role that they play in life, medicine and industry. Conformational aspects of heterocyclic chemistry, aromatic stabilization, nomenclature, reaction mechanisms and methods of synthesis are also discussed. Ideal for the needs of undergraduate chemistry students, Tutorial Chemistry Texts is a major series consisting of short, single topic or modular texts concentrating on the fundamental areas of chemistry taught in undergraduate science courses. Each book provides a concise account of the basic principles underlying a given subject, embodying an independent-learning philosophy and including worked examples.

Organic synthesis, the disconnection approach, Warren, 2nd, ingles

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One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course. 

Organic Synthesis: The Disconnection Approach, 2^nd Edition introduces this important technique, to help students to design their own organic syntheses. There are forty chapters: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems.

Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given.

This second edition has been fully revised and updated with a modern look. Recent examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, “Organic Synthesis: Strategy and Control”.

Heterocyclic chemistry at a glance, Joule, ingles

por capitulos

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Heterocyclic chemistry is a central part of organic chemistry and biochemistry, dealing with a particular set of chemical structures; organic compounds with a ring structure containing at least one heteroatom (commonly nitrogen, oxygen or sulfur).

Heterocyclic Chemistry at a Glance, Second Edition provides both an introduction and summary of the main principles and reactions of heterocyclic chemistry, for students studying chemistry and related courses at undergraduate level. 

This second edition has been much expanded, allowing for a more thorough treatment of key principles and the inclusion of extra examples and illustrations, including heterocycles used in electronics, explosives, polymers, dyestuffs, pigments and that occur in food. All chapters have been revised and updated, including references to books and reviews, and student exercises, with answers on line at http://booksupport.wiley.com. New to this edition is the use of colour in schemes and diagrams highlighting parts of products (or intermediates) where a change in structure or bonding has taken place.

Based on the highly successful and student-friendly “at a glance” approach, the material developed in this book has been chosen to help the student grasp the essence of heterocyclic chemistry, ensuring that they can confidently use that knowledge when required. The structure of the book allows for quick assimilation, understanding and recall of key concepts, facts and definitions, providing an invaluable aid to revision for students preparing for examinations.

Color Atlas of immunology

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A pocket atlas flexibook on this dynamic and wide-ranging field, indispensable for students of medicine and biology alike. Complex processes are well-illustrated in clear images that are not burdened with unnecessary details.

Following an introductory part and a section on laboratory methods in immunology, the bulk of the book concentrates on the manifestations of immunological diseases in the human body, providing comprehensive capsule descriptions of all common immune diseases.

Patología estructural y funcional, Kumar, Robbins, 8va

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Nueva edición de esta prestigiosa obra de primera elección para el estudio de la Anatomía Patológica y que debido a su extraordinaria practicidad continúa siendo ampliamente utilizada por los profesionales clínicos tras haber concluido sus estudios.
Extraordinariamente actualizada, ofrece los últimos avances en el contexto de la ciencia médica básica y de su aplicación clínica. Fotografías de la máxima calidad e ilustraciones en color sirven de apoyo a la nueva información sobre biología molecular, clasificación de enfermedades, nuevos fármacos y tratamientos, pruebas moleculares y genéticas, y sobre los mecanismos de la enfermedad con nuevos cuadros de tratamientos dirigido que analizan los abordajes farmacológicos de enfermedades específicas.
Se ha añadido un capítulo nuevo al inicio del libro "La célula como unidad de salud y enfermedad", en el que se recogen todos aquellos aspectos pertenecientes a la biología molecular y celular y que los autores consideran fundamentales para la comprensión de los aspectos más específicos descritos más adelante.
Acceso a StudentConsult en inglés al contenido completo del libro, casos prácticos interactivos, vídeos y preguntas de autoevaluación.
 En la nueva edición destacan las siguientes novedades:

- Se han incorporado a lo largo del todo el texto unos cuadros de "Key concepts" separados del texto y fácilmente reconocibles por su fondo de color azul. Están escritos en forma de bullet points recogiendo lo más relevante del contenido que se está describiendo. Un mismo capítulo puede contener hasta 6 ó 7 cuadros "Key Concepts"
- Se han eliminado a lo largo de todo el libro las referencias bibliográficas y se han sustituido por un bloque de lecturas recomendadas al final de cada capítulo.
- A pesar de la enorme expansión de la medicina genómica en la que han aparecido múltiples patologías asociadas a las líneas celulares germinales, a lo largo del libro se ha procurado resaltar solamente aquellas que son más comunes y más informativas en términos patogénicos.
- Se ha añadido un capítulo nuevo al inicio del libro: "The Cell as a Unit of Health and Disease", en el que se recogen todos aquellos aspectos pertenecientes a la biología molecular y celular y que los autores consideran fundamentales para la comprensión de los aspectos más específicos descritos más adelante. Como anécdota comentar que la última vez que se añadió un capítulo fue en 1967, por lo que éste es un importante hito en la historia de este título.
* La nueva edición incorpora StudentConsult.com en inglés con un gran número de recursos didácticos.

Natural products from plants, Leland J. Cseke

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From medicinal, industrial, and culinary uses to cutting-edge laboratory techniques in modern research and plant conservation strategies, Natural Products from Plants, Second Edition reveals a vastly expanded understanding of the natural products that plants produce. In a single volume, this bookoffers a thorough inventory of the various types of plant-derived compounds. It covers their chemical composition, structure, and properties alongside the most effective ways to identify, extract, analyze, and characterize new plant-derived compounds. 

The authors examine new information on the chemical mechanisms plants use to deter predators and pathogens, attract symbiotic organisms, and defend themselves against environmental stress—insights which are key for adapting such mechanisms to human health. Along with updated and revised information from the highly acclaimed first edition, the second edition presents seven new chapters and features more than 50% new material relating to plant constituents, natural product biochemistry, and molecular biology. The book incorporates in-depth treatment of natural product biosynthesis with new collection and extraction protocols, advanced separation and analytical techniques, up-to-date bioassays, as well as modern molecular biology and plant biotechnology for the production of natural products. 

Unique in its breadth and coverage, Natural Products from Plants, Second Edition belongs on the shelf of interested researchers, policymakers, and consumers— particularly those involved in disease prevention, treatment, and pharmaceutical applications—who need a complete guide to the properties, uses, and study of plant natural products.

Medicinal natural products, A biosynthetic approach, Paul M. Dewick

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Description

Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine.

There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions:

• a comprehensive treatment of plant, microbial, and animal natural products in one volume
• extensive use of chemical schemes with annotated mechanistic explanations
• cross-referencing to emphasize links and similarities
• boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action

Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.