photostability of drugs and drug formulations, Hanne Hjorth Tønnesen, 2nd, ingles

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Providing the guidance needed for formulation, handling, and quality control of photolabile drugs, Photostability of Drugs and Drug Formulations, Second Edition explores the significance of new information on drug photoreactivity in a pharmaceutical context. Completely revised and updated, with chapter authors drawn from an international panel of experts, the book supplies the background necessary for planning standardized photochemical stability studies as a part of drug development and formulation work. It contains comprehensive coverage of the physical and chemical aspects of drug photoreactivity, formulation, stability testing, and drug design/discovery in one resource.

The contents have been reorganized to focus on the standardization of photostability testing of drug substances and products, in vitro photoreactivity screening of drugs, and various aspects of the formulation of photoreactive substances. The information on in vitro screening of drug photoreactivity is of great relevance for scientists who are developing and validating a set of testing protocols to address photosafety. Discussing kinetic and chemical aspects of drug photodecomposition as well as the practical problems frequently encountered in photochemical stability testing, this book helps you design a test protocol and interpret the results.

Features

Assists non-experts in this field design a test protocol and interpret the results

Covers in vitro and in vivo aspects of interactions between drugs and light

Explores the kinetic and chemical aspects of drug photodecomposition

Discusses the problems frequently encountered in photochemical stability testing

Provides guidance on how to address photosafety assessments and labeling requirements of potentially photoreactive drugs

Highlights the practical implications of drug photodecomposition from a pharmaceutical viewpoint

Offers specific guidance in photostability testing and screening of drug photoreactivity

HPLC methods for pharmaceutical analysis, George Lunn, Norman Scmuff

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Lets you target the specific information you need quickly and easily -so you can stay in the lab and out of the library. This invaluable database -available in print and electronic form -gives you fast, hands-on access to the most significant literature available on HPLC for the analysis of over 150 of the most frequently prescribed pharmaceutical compounds. Combining full descriptions of procedures with specially annotated references, HPLC Methods for Pharmaceutical Analysis helps you to identify the techniques that are relevant to your individual project needs -eliminating hours of tedious, time-consuming library research. Analytical chemists and researchers will find a battery of useful features that make this practical new resource a welcome addition to their reference library: Techniques for each compound are described in detail -enabling replication of a procedure without reference to the original publication Detailed procedures for each drug are listed together -making it easy to combine features of different methods into a customized approach Drug assay methods are provided for drugs in biological fluids such as blood or urine, as well as for bulk and formulated drugs Other key information includes chemical structures, molecular weights and formulas, CAS Registry Numbers, and cross-references to The Merck Index and Chemistry of Drug Synthesis The electronic version, available on CD-ROM, allows you to search the entire database by compound, matrix, HPLC variables, and author.